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Department of Biomedical Engineering, NTU


  1. Journal Papers (*: corresponding author)

    1. Cheng-Hung How, Pei-Hsing Chen, Yu-Ching Chen, Yong-Chong Lin, Ke-Cheng Chen, Tai-Horng Young*. Mechanical and biological properties of poly-ε-caprolactone membrane for pleurodesis: A preclinical study in pigs. Journal of the Formosan Medical Association (2024).
    2. Cheng-Hung How, Pei-Hsing Chen, Yu-Ching Chen, Yong-Chong Lin, Ke-Cheng Chen*, Jin-Shing Chen, Tai-Horng Young*. Safety assessment of poly-ε-caprolactone in the treatment of primary spontaneous pneumothorax. Frontiers in Surgery 11 (2024): 1335144.
    3. Chun-Wei Li, Tai-Horng Young, Mu-Hui Wang, Ming-Ying Pei, Tsung-Yu Hsieh, Chia-Lang Hsu & Nai-Chen Cheng. Low-glucose culture environment can enhance the wound healing capability of diabetic adipose-derived stem cells. Stem Cell Res Ther 14, 236 (2023).
    4. Li-Hui Tsai, Tai-Horng Young, Chia-Hsiang Yen, Wei-Cheng Yao, Chih-Hao Chang, Intratumoral thermo-chemotherapeutic alginate hydrogel containing doxorubicin loaded PLGA nanoparticle and heating agent. International Journal of Biological Macromolecules 251 (2023): 126221.
    5. Yu-Yun Gao, You-Ren Ji, Yi-Hua Hsu, Fang-Chun Liao, Nien-Tzu Kao, Abel Po-Hao Huang*, and Tai-Horng Young*. Gelatin-Based Hydrogel for Three-Dimensional Neuron Culture Application. ACS omega 8.48 (2023): 45288-45300
    6. Hsin-Yuan Tan, Yueh-Feng Wu, Chia-Yi Wang, Sung-Jan Lin, Yunn-Hwa Ma, Tai-Horng Young*. The cellular responses of corneal fibroblasts to cyclic stretching loads. Experimental Eye Research 237 (2023): 109696.
    7. Tzu-Hao Tseng, Chien-Lin Chen, Chung-Hsun Chang, Jyh-Horng Wang & Tai-Horng Young*. IL-6 induces periostin production in human ACL remnants: a possible mechanism causing post-traumatic osteoarthritis. Journal of Orthopaedic Surgery and Research 18.1 (2023): 824
    8. Ting-Chun Lin, Yi-Chieh Tsai, Yun-An Chen, Tai-Horng Young, Chung-Che Wu, Yung-Hsiao Chiang, Chia-Hsin Kao, Abel Po-Hao Huang, Yi-Hua Hsu, Kai-Yun Chen*, Li-Kai Tsai. Brain-derived neurotrophic factor contributes to neurogenesis after intracerebral hemorrhage: a rodent model and human study. Frontiers in Cellular Neuroscience 17 (2023): 1170251.
    9. Chia-Hsiang Yen, Nai-Chen Cheng, Hao-Ying Hsieh, Ching-Wen Tsai, An-Li Lee, Chien-Yi Lu, Yin-Tzu Chen, Tai-Horng Young*. pH-driven continuous stem cell production with enhanced regenerative capacity from polyamide/chitosan surfaces. Materials Today Bio 18 (2023): 100514.
    10. Yu-Chun Lin, Yuan Luo, Ying-Ju Chen, Huei-Wen Chen, Tai-Horng Young, and Hsuan-Ming Huang, "Single-shot quantitative phase contrast imaging based on deep learning," Biomed. Opt. Express 14, 3458-3468 (2023)
    11. Chien-An Liao, Ling-Wei Kuo, Jen-Fu Huang, Chih-Yuan Fu, Szu-An Chen, Yu-San Tee, Chi-Hsun Hsieh, Chien-Hung Liao, Chi-Tung Cheng, Tai-Horng Young, Chih-Po Hsu*. Timely surgical fixation confers beneficial outcomes in patients’ concomitant flail chest with mild-to-moderate traumatic brain injury: a trauma quality improvement project analysis–a cohort study. International Journal of Surgery 109.4 (2023): 729-736.
    12. Yu-Hsun Chiu, I-Cheng Chen, Tzu-Han Lin, Tai-Horng Young, Hsu-Wei Fang. Effects of chitosan on chondrocytes derived from human nasal septal cartilage. in vivo 37.5 (2023): 2001-2005.
    13. Hao-Ying Hsieh, Chung-Chen Yao, Li-Fang Hsu, Li-Hui Tsai, Jiiang-Huei Jeng, Tai-Horng Young, Yi-Jane Chen, Biological properties of human periodontal ligament cell spheroids cultivated on chitosan and polyvinyl alcohol membranes. J Formos Med Assoc. 2022 Nov;121(11):2191-2202.
    14. An-Li Lee, Hao-Ying Hsieh, Yun-Yu Chen, Li-Hui Tsai, Shiuan-Li Wey, Dai-Shi Chen, Yi-Jane Chen, Tai-Horng Young, Novel Application of Photo-Crosslinked Urocanic-Acid-Modified Chitosan in Corneal Wounds. ACS Biomater Sci Eng. 2022 May 9;8(5):2016-2027.
    15. You-Ren Ji, Ya-Hsiang Hsu, Ming-Hua Syue, Ying-Chu Wang, Shyr-Yi Lin, Tsung-Wei Huang, Tai-Horng Young, Controlled Decomposable Hydrogel Triggered with a Specific Enzyme. ACS Omega. 2022 Jan 21;7(4):3254-3261.
    16. Shu-Jyuan Yang, Chih-Hao Chang, Tai-Horng Young, Chung-Hao Wang, Tzu-Hao Tseng, Man-Ling Wang, Human serum albumin-based nanoparticles alter raloxifene administration and improve bioavailability. Drug Deliv. 2022 Dec;29(1):2685-2693.
    17. Yu-Hsun Chiu, I-Cheng Chen, Chen-Ying Su, Hsin-Hua Tsai, Tai-Horng Young, Hsu-Wei Fang, Development of Injectable Calcium Sulfate and Self-Setting Calcium Phosphate Composite Bone Graft Materials for Minimally Invasive Surgery. Int J Mol Sci. 2022 Jul 8;23(14):7590.
    18. Ching-Chia Cheng, Chih-Feng Lin, Yong-Chong Lin, Tai-Horng Young, Pei-Jen Lou, Overexpression of N-acetylglucosaminyltransferase V promotes human parotid gland acinar cell immortalization via the epidermal receptor activation. J Cell Physiol. 2022 Mar;237(3):1780-1789.
    19. Cheng-Jung Yao, Shu-Jyuan Yang, Chung-Huan Huang, Yuan-Ting Chang, Chung-Hao Wang, Ming-Jium Shieh, Tai-Horng Young, Retention Time Extended by Nanoparticles Improves the Eradication of Highly Antibiotic-Resistant Helicobacter pylori. Pharmaceutics. 2022 Oct 5;14(10):2117.
    20. Tzu-Hao Tseng , Chih-Hao Chang, Chien-Lin Chen, Hongsen Chiang, Hao-Ying Hsieh, Jyh-Horng Wang*, Tai-Horng Young*, A simple method to improve the antibiotic elution profiles from polymethylmethacrylate bone cement spacers by using rapid absorbable sutures. BMC Musculoskelet Disord. 2022 Oct 14;23(1):916.
    21. Chia-Hsiang Yen, Nai-Chen Cheng, Hao-Ying Hsieh, Ching-Wen Tsai, An-Li Lee, Chien-Yi Lu, Yin-Tzu Chen, Tai-Horng Young, pH-driven continuous stem cell production with enhanced regenerative capacity from polyamide/chitosan surfaces. Mater Today Bio. 2022 Dec 7;18:100514.
    22. Atikah Haneef, Ramprasad Obula Giridhara Gopalan, Divya T Rajendran, Jessica Nunes, Dharmalingam Kuppamuthu, Naveen Radhakrishnan, Tai-Horng Young, Hao-Ying Hsieh, Namperumalsamy Venkatesh Prajna, Colin E Willoughby, Rachel Williams, Chemical Cross-Linking of Corneal Tissue to Reduce Progression of Loss of Sight in Patients With Keratoconus. Transl Vis Sci Technol. 2021 Apr 29;10(5):6.
    23. Shadie Hatamie, Po-Jen Shih, Bo-Wei Chen, Hua-Ju Shih, I-Jong Wang, Tai-Horng Young, Da-Jeng Yao, Effects of Electromagnets on Bovine Corneal Endothelial Cells Treated with Dendrimer Functionalized Magnetic Nanoparticles. Polymers (Basel). 2021 Sep 28;13(19):3306.
    24. You-Ren Ji, Ching-Chia Cheng, An-Li Lee, Jonathan Chang-Cheng Shieh, Hsin-Ju Wu, Abel Po-Hao Huang, Yi-Hua Hsu, Tai-Horng Young, Poly(allylguanidine)-Coated Surfaces Regulate TGF-β in Glioblastoma Cells to Induce Apoptosis via NF-κB Pathway Activation. ACS Appl Mater Interfaces. 2021 Dec 15;13(49):59400-59410.
    25. Ching-Cheng Tsai, Tai-Horng Young, Guang-Shih Chen, Nai-Chen Cheng, Developing a Glyoxal-Crosslinked Chitosan/Gelatin Hydrogel for Sustained Release of Human Platelet Lysate to Promote Tissue Regeneration. Int J Mol Sci. 2021 Jun 16;22(12):6451.
    26. You-Ren Ji, Tai-Horng Young, Ting-Yu Tsai, Jin-Shing Chen, Ke-Cheng Chen, Dopamine-Modified Alginate Hydrogel with Effectiveness and Safety for Preoperative Localization of Lung Nodules. ACS Biomater Sci Eng. 2021 Sep 13;7(9):4637-4644.
    27. Sheng-Tien Li, Tai-Horng Young, Tsung-Wei Huang, Regeneration of olfactory neuroepithelium in 3-methylindole-induced anosmic rats treated with intranasal chitosan. Biomaterials. 2021 Apr;271:120738.
    28. Chien-An Liao, Tai-Horng Young, Chi-Tung Cheng, Ling-Wei Kuo, Chih-Yuan, Chih-Po Hsu, Szu-An Chen, Yu-San Tee, Chih-Hsun Hsieh, Chih-Chi Chen, Chien-Hung Liaom, The Feasibility and Efficiency of Remote Spirometry System on the Pulmonary Function for Multiple Ribs Fracture Patients. J Pers Med. 2021 Oct 23;11(11):1067.
    29. LH Tsai, CH Yen, HY Hsieh, TH Young*, Doxorubicin loaded PLGA nanoparticle with cationic/anionic polyelectrolyte decoration: characterization, and its therapeutic potency, Polymers, 13 (2021) 693.
    30. CH Yen, TH Young (co-first author), TW Huang, Cell detachment ratio on pH-responsive chitosan: a useful biometric for prognosis judgment and drug efficacy assessment in oncology, Carbohyd. Polym., 261 (2021) 117911.
    31. NC Cheng, YK Tu, NH Lee, TH Young*, Influence of human platelet lysate on extracellular matrix deposition and cellular characteristics in adipose-derived stem cell sheets, Front. Cell Dev. Biol., 8 (2020) 558354.
    32. SH, PJ Shih, BW Chen, IJ Wang, TH Young, DJ Yao, Synergic effect of novel WS2 carriers holding spherical cobalt ferrite @cubic Fe3O4 (WS2/s-CoFe2O4@c-Fe3O4) nanocomposites in magnetic resonance imaging and photothermal therapy for ocular treatments and investigation of corneal endothelial cell migration, Nanomaterials 10 (2020) 2555.
    33. S Fadera, NC Cheng, TH Young*, IC Lee, In vitro study of SDF-1α-loaded injectable and thermally responsive hydrogels for adipose stem cell therapy by SDF-1/CXCR4 axis, J. Mat. Chem. B, 8 (2020) 10360-10372.
    34. HH Chang, NC Cheng, YC E Li, JH Wang, TH Young*, pH-responsive characteristics of chitosan-based blends for controlling the adhesivity of cells, J. Taiwan Inst. Chem. E., 111 (2020) 34-43.
    35. S Homaeigohar, TY Tsai, ES Zariec, M Elbahri, TH Young, AR Boccaccini, Bovine serum albumin (BSA)/polyacrylonitrile (PAN) biohybrid nanofibers coated with a biomineralized calcium deficient hydroxyapatite (HA) shell for wound dressing, Mater. Sci. Eng. C-Mater. Biol. Appl., 116 (2020)111248.
    36. YC E Li, JH Wang, YH Wang, HJ Shao, LC Young, TH Young*, PCL-blended chitosan substrates for patterning the heterotypic cell distribution in an epithelial and mesenchymal coculture system, ACS Biomater. Sci. Eng., 6 (2020) 4225-4235.
    37. SJ Yang, SY Tseng, CH Wang, TH Young, KC Chen, MJ Shieh, Magnetic nanomedicine for CD133-expressing cancer therapy using locoregional hyperthermia combined with chemotherapy, Nanomedicine (Lond.), 15 (2020) 2543–2561.
    38. HY Hsieh, WY Lin, AL Lee, YC Li, YJ Chen, KC Chen, TH Young*, Hyaluronic acid on the urokinase sustained release with a hydrogel system composed of Poloxamer 407:HA/P407 hydrogel system for drug delivery, PLoS One, 15 (2020) e0227784.
    39. YA Chen, YC Tsai, ID Chen, DZ Liu, TH Young*, Li-Kai Tsai, Intraventricular Medium B Treatment Benefits an Ischemic Stroke Rodent Model via Enhancement of Neurogenesis and Anti-apoptosis, Sci. Rep., 10 (2020) 6596.
    40. CH Yen, ST Li, NC Cheng, YR Ji, JH Wang, TH Young*, Label-free platform on pH-responsive chitosan: adhesive heterogeneity for cancer stem-like cell isolation from A549 cells via integrin β4, Carbohyd. Polym., 239 (2020)116168.
    41. HW Chen, YS Chou, TH Young*, NC Cheng, Inhibition of melanin synthesis and melanosome transfer by chitosan biomaterials, J. Biomed. Mater. Res. B, 108 (2020) 1239-1250.
    42. Y Cheng, KH Lin, TH Young, NC Cheng, The influence of fibroblast growth factor 2 on the senescence of human adipose-derived mesenchymal stem cells during long-term culture, Stem Cells Transl. Med., 9 (2020) 518-530.
    43. HC Tsai, JH Wang, YA Chen, LK Tsai, TH Young*, YC Ethan Li, A self-assembled layer-by-layer surface modification to fabricate the neuron-rich model from neural stem/precursor cells, J. Formos. Med. Assoc., 119 (2020) 430-438.
    44. CH Wu, MK Sun, Y Kung, YC Wang, SL Chen, HH Shen, WS Chen, TH Young*, One injection for one-week controlled release: in vitro and in vivo assessment of ultrasound-triggered drug release from injectable thermoresponsive biocompatible hydrogels, Ultrason. Sonochem., 62 (2020) 104875.
    45. TW Huang, ST Li, DY Chen, TH Young*, Neuropeptide Y increases differentiation of human olfactory receptor neurons through the Y1 receptor, Neuropeptides, 78 (2019) 101964.
    46. CH Yen, TH Young, MC Hsieh, LJ Liao, TW Huang, Increased cell detachment ratio of mesenchymal-type lung cancer cells on pH-responsive chitosan through integrin β3, Marine Drugs,17 (2019) 659.
    47. S Homaeigohar, TY Tsai, TH Young, HJ Yang, YR Ji, An electroactive citric acid functionalized graphite nanofilament-calcium alginate hydrogel nanocomposite for neural tissue engineering, Carbohyd. Polym., 224 (2019) 115112.
    48. WC Huang, SC Lo, DT Lin, JH Wang, TH Young*, The application of 4T-PET fibers/nonwovens for leucocyte filters, J. Ind. Text., 49 (2019) 633-647.
    49. TW Huang, ST Li, YH Wang, TH Young*, Regulation of chitosan-mediated differentiation of human olfactory receptor neurons by insulin-like growth factor binding protein-2, Acta Biomater., 97 (2019) 399-408.
    50. YH Wang, TH Young, TJ Wang, Investigating the effect of chitosan/ polycaprolactone blends in diff erentiation of corneal endothelial cells and extracellular matrix compositions, Exp. Eye Res., 185 (2019) 107679.
    51. TW Huang, ST Li, TH Young*, Chitosan-hyaluronan: Promotion of mucociliary differentiation of respiratory epithelial cells and development of olfactory receptor neurons, Artif. Cell Nanomed. Biotechnol., 47 (2019) 564-570.
    52. JL Wang, YC Lin, TH Young*, MH Chen, Far-infrared ray radiation promotes neurite outgrowth of neuron-like PC12 cells through AKT1 signaling, J. Formos. Med. Assoc., 118 (2019) 600-610.
    53. HW Lee, YC Hsiao, YC Chen, TH Young, TL Yang, Salispheres from Different Major Salivary Glands for Glandular Regeneration, J. Dent. Res., 98 (2019) 786-794.
    54. CH How, CW Lin, YC Lin, TH Young*, KC Chen, JS Chen, Evaluation of pleurodesis by poly-epsilon-caprolactone (PCL) gel in an animal model using New Zealand white rabbits, Asian J. Surg., 42 (2019) 495-500.
    55. TY Tu, SJ Yang, MH Tsai, CH Wang, SY Lee, TH Young, MJ Shieh, Dual-triggered drug-release vehicles for synergistic cancer therapy, Colloid Surface B, 173 (2019) 788-797.
    56. WC Hsaio, TH Young*, Characteristics of melanocyte spheroids formed through different biomaterial-induced processes, J. Formos. Med. Assoc., accepted.
    57. CH Chang, D Mau-Hsu, KC Chen, CW Wei, CY Chiu, TH Young*, Evaluation of digital real-time PCR assay as a molecular diagnostic tool for single-cell analysis, Sci. Rep., accepted.
    58. SH Chang, A Eliasy, KJ Chen, YR Ji, TH Young, TJ Wang, CE Willoughby, KJ Hamill, A Elsheikh, Determination of the relationship between mechanical properties, ultrastructural changes and intrafibrillar bond formation in corneal UVA/riboflavin cross-linking treatment for keratoconus, J. Refract. Surg., accepted.
    59. YA Chen, KC Wang, DZ Liu, TH Young*, LK Tsai, The Proliferation Capacity of Cultured Neural Stem Cells Promoted by CSF Collected from SAH Patients Correlates to Clinical Outcome, Sci. Rep., accepted.
    60. ST Li, TH Young*, TW Huang, Poly (ethylene-co-vinyl alcohol) is a suitable substrate for human olfactory neuroepithelial cell differentiation in vitro through a defined regulatory pathway, Acta Biomater., accepted.
    61. CW Tsai, IN Chiang, JH Wang, TH Young*, Chitosan delaying human fibroblast senescence through downregulation of TGF-β signaling pathway, Artif. Cell Nanomed. Biotechnol., accepted.
    62. IN Chiang, WC Huang, CY Huang, YS Pu, TH Young*, Development of a chitosan-based tissue-engineered renal proximal tubule conduit, J. Biomed. Mater. Res. B, accepted.
    63. YH Wang, SH Chang, D Mau-Hsu, JH Wang, TH Young*, Poly (N-(4-aminobutyl)-acrylamide) as mimetic polylysine for improving survival and differentiation of cerebellar granule neurons, J. Biomed. Mater. Res. B, 106 (2018) 1194-1201.
    64. CH Wu, MK Sun, J Shieh, CS Chen, CW Huang, CA Dai, SW Chang, WS Chen, TH Young*, Ultrasound-responsive NIPAM-based hydrogels with tunable profile of controlled release of large molecules, Ultrasonics, 83 (2018) 157-163.
    65. CH Wang, RW Chang, CY Chang, MS Wu, HL Kao, LC Lai, TH Young, HY Yu, YS Chen, KC Chang, Quantification of contractile mechanics in the rat heart from ventricular pressure alone, Oncotarget, 8 (2017) 96161-96170.
    66. IN Chiang, WC Huang, CY Huang, YS Pu, TH Young*, Far infrared radiation promotes rabbit renal proximal tubule cell proliferation and functional characteristics, and protects against cisplatin-induced nephrotoxicity, PLoS One, 12 (2017) e0180872.
    67. ST Li, TH Young, CF Lin, TW Huang, Promotion of olfactory receptor neuron differentiation of olfactory neuroepithelial cells using chitosan solution. Am. J. Rhinol. Allergy, 31 (2017) 289-292.
    68. KC Chen, MS Hsieh, YR Li, YC Lin, HS Lai, MJ Shieh, JS Chen, TH Young*, Study of poly-ε-caprolactone (PCL) membranes for pleurodesis, J. Formos. Med. Assoc., 116 (2017) 880-887.
    69. YC Li, K Zhu, TH Young*, Induced Pluripotent stem cells, form in vitro tissue engineering to in vivo allogeneic transplantation, J Thorac. Dis., 9 (2017) 455-459.
    70. IN Chiang, CY Huang, YS Pu, CH Chang, CH Muo, CJ Chung, RY Wang, TH Young*, Association between ischemic bowel syndromes and androgen-deprivation therapy in prostate cancer patients: a retrospective cohort study, BMJ Open, 7 (2017) e012950.
    71. NC Cheng, WC Lin, TY Ling, TH Young*, Sustained Release of Adipose-Derived Stem Cells by Thermosensitive Chitosan-Gelatin Hydrogel for Therapeutic Angiogenesis, Acta Biomater., 51 (2017) 258-267.
    72. MC Lin, YC Lin, ST Chen, TH Young*, PJ Lou, Therapeutic vaccine targeting Epstein-Barr virus latent protein, LMP1, suppresses LMP1 expressing tumor growth and metastasis in vivo, BMC cancer, 17 (2017) 18.
    73. RW Chang, CY Chang, LC Lai, MS Wu, TH Young, YS Chen, CH Wang, KC Chang, Determining arterial wave transit time from a single aortic pressure pulse in rats: vascular impulse response analysis, Sci. Rep., 7(2017) 40998.
    74. TJ Wang, IJ Wang, FR Hu, TH Young, Applications of Biomaterials in Corneal Endothelial Tissue Engineering, Cornea 35 (2016) S25-S30.
    75. CH Yang, YW Pan, JJ Guo, TH Young, WY Chiu, KH Hsieh, Synthesis and application of polyurethane basic organic-inorganic hybrid materials as highly hydrophobic coatings, J. Polym. Res., 23 (2016) 29.
    76. CW Tsai, TH Young*, CD44 expression trends of mesenchymal stem-derived cell, cancer cell and fibroblast spheroids on chitosan-coated surfaces, Pure. Appl. Chem., 88 (2016) 843-852.
    77. YS Chou, YC Lin, TH Young*, PJ Lou, Effects of fibroblasts on the function of acinar cells from the same human parotid gland, Head Neck-J. Sci. Spec., 38 (2016) E279-E286.
    78. CH Yang, YW Pan, JJ Guo, TH Young, WY Chiu, KH Hsieh, Synthesis and application of polyurethane basic organic-inorganic hybrid materials as highly hydrophobic coatings, J. Polym. Res., accepted.
    79. NC Cheng, TY Hsieh, TH Young*, High glucose-induced reactive oxygen species generation promotes stemness in human adipose-derived stem cells, Cytotherapy, accepted.
    80. HC Tsai, YC Li, TH Young, MH Chen,Inhibition of oral and cervical cancer cell growth and migration by citrus polyphenol, J. Formos. Med. Assoc., accepted.
    81. HC Tsai, YC Li, TH Young, MH Chen, Novel micro-injector for carrying bone substitutes for bone regeneration in periodontal diseases, J. Formos. Med. Assoc., accepted.
    82. HC Tsai, YC Li, TH Young, MH Chen, Citrus polyphenol for oral wound healing in oral ulcers and periodontal diseases, J. Formos. Med. Assoc., accepted.
    83. YS Chou, YC Lin, TH Young*, PJ Lou, Effects of fibroblasts on the function of acinar cells from the same human parotid gland, Head Neck-J. Sci. Spec., accepted.
    84. YC Li, LK Tsai, TH Young*, Intraventricular infusion of a low fraction of serum enhances neurogenesis and improves recovery in a rodent stroke model, Neurosci Lett., 611 (2016) 14-20.
    85. YC Li, MW Lin, MH Yen, MY Fan, JT Wu, TH Young, JY Cheng, SJ Lin, Programmable laser-assisted surface microf TH abrication on a polyvinyl alcohol-coated glass chip with self-changing cell adhesivity for heterotypic cell patterning, ACS Appl. Mater. Inter., 7 (2015) 22322-22332.
    86. CW Tsai, YT Kao, IN Chiang, JH Wang, TH Young*, Chitosan treatment delays the induction of senescence in human foreskin fibroblast strains, PLoS One, 10 (2015), e0140747.
    87. YS Chou, JN Lu, YC Li, JH Wang, TH Young*, The surface potential variation of neural stem/progenitor cells during differentiation process. Journal of Neurology & Neuroscience, 6 (2015) No. 3:38.
    88. YJ Chen, CCJ Yao, CH Huang, HH Chang, TH Young*, Hexosamine-induced TGF-ß signaling and osteogenic differentiation of dental pulp stem cells is dependent on N-acetylglucosaminyltransferase V (GnT-V), BioMed Res. Int., (2015) 924397, 11 pages.
    89. YS Chou, TH Young*, PJ Lou, Effects of biomaterial-derived fibroblast conditioned medium on the a-amylase expression of parotid gland acinar cells, Acta Biomater., 27 (2015) 214–223.
    90. YC Li, JH Wang, LK Tsai, TL Yang, YA Chen, TC Chang, PJ Lou, TH Young*, 3,6-Bis(1-methyl-4-vinylpyridinium)-carbazole diiodide as a marker for tracking living neural stem/ precursor cells, J. Mat. Chem. B, 3 (2015) 2067-2074
    91. CH Yang, SH Chen, YW Pan, CN Chuang, WC Chao, TH Young, WY Chiu, CK Wang, KH Hsieh, Preparation and characterization of methoxy-poly (ethylene glycol) side chain grafted onto chitosan as a wound dressing film, J. Appl. Polym. Sci., 132 (2015) 42340.
    92. TW Huang, TH Young*, Novel porous oral patches for mild obstructive sleep apnea patients with mouth-breathing: A pilot study, Otolaryngol. Head Neck Surg., 152 (2015) 369-373.
    93. YC Li, LK Tsai, TL Yang, YA Chen, TC Chang, PJ Lou, TH Young*, A novel bio-marker for tracking viable neural stem/precursor cells, J. Mat. Chem. B, 3 (2015) 2067-2074.
    94. IC Lee, TL Lo, TH Young, YC Li, NG Chen, CH Chen, YC Chang, Differentiation of neural stem/progenitor cells using low-intensity ultrasound, Ultrasound Med. Biol. 40 (2014) 2195-2206.
    95. YH Chen, SH Chang, IJ Wang, TH Young*, The mechanism for keratinocyte detaching from pH-responsive chitosan, Biomaterials, 35 (2014) 9247-9254.
    96. YC Lin, PJ Lou, TH Young*, Chitosan as an adjuvant-like substrate for dendritic cell culture to enhance antitumor effects, Biomaterials, 35 (2014) 8867-8875.
    97. TH Young, IJ Wang, FR Hu, TJ Wang, Fabrication of a bioengineered corneal endothelial cell sheet using chitosan/polycaprolactone blend membranes, Colloid Surface B, 116 (2014) 403-410.
    98. CH Wang, RW Chang, YH Ko, PR Tsai, SS Wang, YS Chen, WJ Ko, CY Chang, TH Young, KC Chang, Prevention of arterial stiffening by using low-dose atorvastatin in diabetes is associated with decreased malondialdehyde, PLoS One, 9 (2014) e90471
    99. YC Li, LK Tsai, JH Wang, TH Young*, A neural stem/precursor cell monolayer for neural tissue engineering, Biomaterials, 35 (2014) 1192-1204.
    100. TL Yang, L Lin, PJ Lou, TC Chang, TH Young*, Detection of cell carcinogenic transformation by a quadruplex DNA binding fluorescent probe, PLoS One, 9 (2014) e86143.
    101. CH Chen, TH Young, CH Huang, HH Chang, CL Chen, HF Chien, JS Chen, HS Lai, NC Cheng, Patient-centered wound teleconsultation for cutaneous wounds: a feasibility study, Ann. Plast. Surg., 72 (2014) 220-224.
    102. CH Hung, YC Li, TH Young*, Induction of neuronal differentiation of embryonic rat cortical neurospheres by nerve growth factor and fetal bovine serum on the nonadherent and adherent substrates, Biomed. Eng.-Appl. Basis Commun., 25 (2013) 1250053.
    103. HY Tan, W Lo, CM Hsueh, CY Wang, SJ Lin, CY Dong, TH Young*, Characterizing three-dimensional microstructure of collagen/chitosan scaffolds using multiphoton microscope, Biomed. Eng.-Appl. Basis Commun., 25 (2013) 1350038.
    104. SH Chang, IN Chiang, YH Chen, TH Young*, Serum-free culture of rat proximal tubule cells with enhanced function on chitosan, Acta Biomater., 9 (2013) 8941-8951.
    105. TW Huang, YH Chan, HW Su, YS Chou, TH Young*, Increased mucociliary differentiation and aquaporins formation of respiratory epithelial cells on retinoic acid-loaded hyaluronan derivative membranes, Acta Biomater., 9 (2013) 6783-6789.
    106. HH Lee, CC Chang, MJ Shieh, JP Wang, YT Chen, TH Young*, SC Hung, Hypoxia enhances chondrogenesis and prevents terminal differentiation through PI3K/Akt/FoxO dependent anti-apoptotic effect, Sci. Rep., 3 (2013) 2683.
    107. NC Cheng, SY Chen, JR Li, TH Young*, Short-term spheroid formation enhances the regenerative capacity of adipose-derived stem cells by promoting stemness, angiogenesis and chemotaxis, Stem Cells Transl. Med., 2 (2013) 584-594.
    108. CC Lin, CC Wang, KC Hung, CL Chen, CC Yong, TH Young, E Kobayash, Study of porcine hepatocyte-entrapped bioartificial liver in surgery-induced fulminant hepatic failure rabbits, Biochem. Eng. J., 76 (2013) 55-59.
    109. CH Wang, TM Wang, TH Young, YK Lai, ML Yen, The critical role of ECM proteins within the human MSC niche in endothelial differentiation, Biomaterials, 34 (2013) 4223-4234.
    110. HY Tan, YL Chang, W Lo, CM Hsueh, WL Chen, AA Ghazaryan, PS Hu, TH Young, SJ Chen, CY Dong, Characterizing the morphological changes of collagen-crosslinking treated corneas by Fourier transform-second harmonic generation imaging, J. Cataract. Refr. Surg., 39 (2013) 779-788.
    111. NC Cheng, BT Estes, TH Young, F Guilak, Genipin-crosslinked cartilage-derived matrix as a scaffold for human adipose-derived stem cell chondrogenesis, Tissue Eng., 19 (2013) 484-496.
    112. YC Li, YT Liao, HH Chang, TH Young*, Covalent bonding of GYIGSR to EVAL membrane surface to improve migration and adhesion of cultured neural stem/precursor cells, Colloid Surface B, 102 (2013) 53-62.
    113. YC Li, CR Chen, TH Young*, Pearl extract enhances the migratory ability of fibroblasts in a wound healing model, Pharm. Biol., 51 (2013) 289-297.
    114. YS Chou, CC Chang, TC Chang, TL Yang, TH Young*, PJ Lou, Photo-induced antitumor effect of 3,6-bis(1-methyl-4-vinylpyridinium) carbazole diiodide (BMVC), BioMed Research International (J. Biomed. Biotechnol.), Volume 2013, Article ID 930281, 10 pages.
    115. YH Chen, SH Chang, TJ Wang, IJ Wang, TH Young*, Cell fractionation on pH-responsive chitosan surface, Biomaterials, 34 (2013) 854-863.
    116. TL Yang, L Lin, YC Hsaio, HW Lee, TH Young*, Chitosan biomaterials induce branching morphogenesis in a model of tissue-engineered glandular organs in serum-free conditions, Tissue Eng., 18 (2012) 2220-2230.
    117. HJ Shao, CC Ho, YT Lee, CS Chen, JH Wang, TH Young*, Chondrogenesis of human bone marrow mesenchymal cells by transforming growth factors ß1 through cell shape changes on controlled biomaterials, J. Biomed. Mater. Res. A, 100A (2012) 3344-3352.
    118. NC Cheng, HH Chang, YK Tu, TH Young*, Efficient transfer of human adipose-derived stem cells by chitosan/gelatin blend films, J. Biomed. Mater. Res. B, 100B (2012) 1369-1377.
    119. YC Li, YC Lin, TH Young*, Combination of media, biomaterials and extra cellular matrix proteins to enhance the differentiation of neural stem/precursor cells into neurons, Acta Biomater., 8 (2012) 3035-3048.
    120. TJ Wang, IJ Wang, JN Lu, TH Young*, Novel chitosan-polycaprolactone blends as potential scaffold and carrier for corneal endothelial transplantation, Mol. Vis., 18 (2012) 255-264.
    121. TJ Wang, IJ Wang, YH Chen, TH Young*, Polyvinylidene fluoride for proliferation and preservation of bovine corneal endothelial cells by enhancing type IV collagen production and deposition, J. Biomed. Mater. Res., 100A (2012) 252-260.
    122. BY Yu, PY Chen, YM Sun, YT Lee, TH Young, Response of human mesenchymal stem cells (hMSCs) to the topographic variation of poly(3-Hydroxybutyrate-co-3-Hydroxyhexanoate) (PHBHHx) films, J. Biomat. Sci-Polym. E., 23 (2012) 1-26.
    123. TJ Wang, IJ Wang, S Chen, YH Chen, TH Young*, The phenotypic response of bovine corneal endothelial cells on chitosan/polycaprolactone blends, Colloid Surface B, 90 (2012) 236-243.
    124. NC Cheng, S Wang, TH Young*, The influence of spheroid formation of human adipose-derived stem cells on chitosan films on stemness and differentiation capabilities, Biomaterials, 33 (2012) 1748-1758.
    125. YH Chen, YC Chung, IJ Wang, TH Young*, Control of cell attachment on pH-responsive chitosan surface by precise adjustment of medium pH, Biomaterials, 33 (2012) 1336-1342.
    126. PC Tseng, TH Young, TM Wang, HW Peng, SM Hou, ML Yen, Spontaneous osteogenesis of MSCs cultured on 3D microcarriers through alteration of cytoskeletal tension, Biomaterials 33 (2012) 556-564.
    127. YJ Chen, MC Chung, CC Yao, CH Huang, HH Chang, JH Jeng, TH Young*, The effect of acellular amniotic membrane matrix on osteogenic differentiation and ERK1/2 signaling in human dental apical papilla cells, Biomaterials 33 (2012) 455-463.
    128. YH Chan, TW Huang, YS Chou, SH Hsu, WF Su, PJ Lou, TH Young*, Formation of post-confluence structure in human parotid gland acinar cells on PLGA through regulation of E-cadherin, Biomaterials 33 (2012) 464-472.
    129. Tsao, C.T., C.H. Chang, Y.Y. Lin, M.F. Wu, J.L. Wang, T.H. Young, J.L. Han, and K.H. Hsieh, Evaluation of chitosan/gamma-poly(glutamic acid) polyelectrolyte complex for wound dressing materials. Carbohydrate Polymers. 84(2): p. 812-819.(2011) (SCI)
    130. Lu, J.N., C.C. Wang, and T.H. Young*, The Behaviors of Long-Term Cryopreserved Human Hepatocytes on Different Biomaterials. Artificial Organs. 35(3): p. E65-E72.(2011) (SCI)
    131. Lee, Y.T., B.Y. Yu, H.J. Shao, C.H. Chang, Y.M. Sun, H.C. Liu, S.M. Hou, and T.H. Young, Effects of the Surface Characteristics of Nano-Crystalline and Micro-Particle Calcium Phosphate/Chitosan Composite Films on the Behavior of Human Mesenchymal Stem Cells In Vitro. Journal of Biomaterials Science-Polymer Edition. 22(17): p. 2369-2388.(2011) (SCI)
    132. Ke, J.H., M.F. Wei, M.J. Shieh, and T.H. Young*, Imidazole/Poly(Ethylene Glycol)-Substituted Poly(N-(8-Aminooctyl)Acrylamide) as Biocompatible and Efficient Gene Carrier. Journal of Biomaterials Science-Polymer Edition. 22(13): p. 1753-1775.(2011) (SCI)
    133. Ke, J.H., M.F. Wei, M.J. Shieh, and T.H. Young*, Design, Synthesis and Evaluation of Cationic Poly(N-substituent acrylamide)s for In Vitro Gene Delivery. Journal of Biomaterials Science-Polymer Edition. 22(9): p. 1215-1236.(2011) (SCI)
    134. Huang, C.W., H.Y. Chen, M.H. Yen, J.J.W. Chen, T.H. Young, and J.Y. Cheng, Gene Expression of Human Lung Cancer Cell Line CL1-5 in Response to a Direct Current Electric Field. PLoS One. 6(10).(2011) (SCI)
    135. Hsieh, C.H., Y.A. Ku, L.H. Chiu, T.H. Young, and Y.Y. Huang, A Transdermal Drug Delivery System Containing Deferioxamine Mesylate for the Treatment of Beta-Thalassaemia Major. Biomedical Engineering-Applications Basis Communications. 23(1): p. 29-35.(2011) (SCI)
    136. Hsiao, Y.C., H.W. Lee, Y.T. Chen, T.H. Young, and T.L. Yang, The impact of compositional topography of amniotic membrane scaffold on tissue morphogenesis of salivary gland. Biomaterials. 32(19): p. 4424-4432.(2011) (SCI)
    137. Chung, Y.C., M.F. Wei, F.H. Chang, and T.H. Young*, PEGylated Guanidinylated Polyallylamine as Gene-Delivery Carrier. Journal of Biomaterials Science-Polymer Edition. 22(14): p. 1829-1843.(2011) (SCI)
    138. Chung, Y.C., T.Y. Cheng, and T.H. Young*, The role of adenosine receptor and caveolae-mediated endocytosis in oligonucleotide-mediated gene transfer. Biomaterials. 32(19): p. 4471-4480.(2011) (SCI)
    139. Cheng, N.C., B.T. Estes, T.H. Young, and F. Guilak, Engineered cartilage using primary chondrocytes cultured in a porous cartilage-derived matrix. Regenerative Medicine. 6(1): p. 81-93.(2011) (SCI)
    140. Chan, Y.H., T.W. Huang, T.H. Young*, and P.J. Lou, Selective Culture of Different Types of Human Parotid Gland Cells. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck. 33(3): p. 407-414.(2011) (SCI)
    141. Chan, Y.H., T.W. Huang, T.H. Young*, and P.J. Lou, Human Salivary Gland Acinar Cells Spontaneously Form Three-Dimensional Structures and Change the Protein Expression Patterns. Journal of Cellular Physiology. 226(11): p. 3076-3085.(2011) (SCI)
    142. Yu, B.Y., P.Y. Chen, Y.M. Sun, Y.T. Lee, and T.H. Young, Effects of the Surface Characteristics of Polyhydroxyalkanoates on the Metabolic Activities and Morphology of Human Mesenchymal Stem Cells. Journal of Biomaterials Science-Polymer Edition. 21(1): p. 17-36.(2010) (SCI)
    143. Young, T.H., H.H. Chang, D.J. Lin, and L.P. Cheng, Surface modification of microporous PVDF membranes for neuron culture. Journal of Membrane Science. 350(1-2): p. 32-41.(2010) (SCI)
    144. Yen, M.H., C.W. Huang, W.C. Hsu, T.H. Young, K. Zimmer, and J.Y. Cheng, Crack-free micromachining on glass substrates by visible LIBWE using liquid metallic absorbers. Applied Surface Science. 257(1): p. 87-92.(2010) (SCI)
    145. Yang, T.L., Y.C. Hsiao, S.J. Lin, H.W. Lee, P.J. Lou, J.Y. Ko, and T.H. Young, Biomaterial mediated epithelial-mesenchymal interaction of salivary tissue under serum free condition. Biomaterials. 31(2): p. 288-295.(2010) (SCI)
    146. Yang, S.J., J.W. Chen, F.H. Lin, T.H. Young, P.J. Lou, and M.J. Shieh, Colorectal Cancer Cell Detection by Folic Acid-Conjugated Chitosan Nanoparticles. Biomedical Engineering-Applications Basis Communications. 22(1): p. 9-17.(2010) (SCI)
    147. Wang, J.H., U.H. Lin, C.H. Lin, Y.C. Chung, C.R. Chen, Y.C. Kao, J.Y. Lai, and T.H. Young*, Change in neuron aggregation and neurite fasciculation on EVAL membranes modified with different diamines. Journal of Biomedical Materials Research Part A. 94A(2): p. 489-498.(2010) (SCI)
    148. Wang, I.J., M.C. Jhuang, Y.H. Chen, L.K. Yeh, C.Y. Liu, and T.H. Young, Chitosan Modification of Adenovirus to Modify Transfection Efficiency in Bovine Corneal Epithelial Cells. PLoS One. 5(8).(2010) (SCI)
    149. Tsai, W.C., C.J. Liao, C.T. Wu, C.Y. Liu, S.C. Lin, T.H. Young, S.S. Wu, and H.C. Liu, Clinical result of sintered bovine hydroxyapatite bone substitute: analysis of the interface reaction between tissue and bone substitute. Journal of Orthopaedic Science. 15(2): p. 223-232.(2010) (SCI)
    150. Shao, H.J., Y.T. Lee, C.S. Chen, J.H. Wang, and T.H. Young, Modulation of gene expression and collagen production of anterior cruciate ligament cells through cell shape changes on polycaprolactone/chitosan blends. Biomaterials. 31(17): p. 4695-4705.(2010) (SCI)
    151. Shao, H.J., C.S. Chen, Y.T. Lee, J.H. Wang, and T.H. Young, The phenotypic responses of human anterior cruciate ligament cells cultured on poly(epsilon-caprolactone) and chitosan. Journal of Biomedical Materials Research Part A. 93A(4): p. 1297-1305.(2010) (SCI)
    152. Lou, P.J., M.Y. Chiu, C.C. Chou, B.W. Liao, and T.H. Young*, The effect of poly (ethylene-co-vinyl alcohol) on senescence-associated alterations of human dermal fibroblasts. Biomaterials. 31(7): p. 1568-1577.(2010) (SCI)
    153. Lee, Y.T., H.J. Shao, J.H. Wang, H.C. Liu, S.M. Hou, and T.H. Young*, Hyaluronic Acid Modulates Gene Expression of Connective Tissue Growth Factor (CTGF), Transforming Growth Factor-beta 1 (TGF-beta 1), and Vascular Endothelial Growth Factor (VEGF) in Human Fibroblast-Like Synovial Cells from Advanced-Stage Osteoarthritis In Vitro. Journal of Orthopaedic Research. 28(4): p. 492-496.(2010) (SCI)
    154. Ke, J.H. and T.H. Young*, Multilayered polyplexes with the endosomal buffering polycation in the core and the cell uptake-favorable polycation in the outer layer for enhanced gene delivery. Biomaterials. 31(35): p. 9366-9372.(2010) (SCI)
    155. Huang, T.W., P.W. Cheng, Y.H. Chan, T.H. Yeh, Y.H. Young*, and T.H. Young, Regulation of ciliary differentiation of human respiratory epithelial cells by the receptor for hyaluronan-mediated motility on hyaluronan-based biomaterials. Biomaterials. 31(26): p. 6701-6709.(2010) (SCI)
    156. Huang, T.W., P.W. Cheng, Y.H. Chan, C.T. Wang, K.M. Fang, and T.H. Young*, Clinical and biomechanical analyses to select a suture material for uvulopalatopharyngeal surgery. Otolaryngology-Head and Neck Surgery. 143(5): p. 655-661.(2010) (SCI)
    157. Huang, T.W., Y.H. Chan, P.W. Cheng, Y.H. Young*, P.J. Lou, and T.H. Young, Increased mucociliary differentiation of human respiratory epithelial cells on hyaluronan-derivative membranes. Acta Biomaterialia. 6(3): p. 1191-1199.(2010) (SCI)
    158. Huang, C.H., W.Y. Tseng, C.C. Yao, J.H. Jeng, T.H. Young*, and Y.J. Chen, Glucosamine Promotes Osteogenic Differentiation of Dental Pulp Stem Cells through Modulating the Level of the Transforming Growth Factor-beta Type I Receptor. Journal of Cellular Physiology. 225(1): p. 140-151.(2010) (SCI)
    159. Chung, Y.C., W.Y. Hsieh, and T.H. Young*, Polycation/DNA complexes coated with oligonucleotides for gene delivery. Biomaterials. 31(14): p. 4194-4203.(2010) (SCI)
    160. Chung, Y.C., F.H. Chang, M.F. Wei, and T.H. Young, A variable gene delivery carrier-biotinylated chitosan/polyethyleneimine. Biomedical Materials. 5(6).(2010) (SCI)
    161. Chang, C.H., C.T. Tsao, K.Y. Chang, J.L. Wang, T.H. Young, J.L. Han, and K.H. Hsieh, Chitosan Membrane with Surface-bonded Growth Factor in Guided Tissue Regeneration Applications. Journal of Bioactive and Compatible Polymers. 25(5): p. 465-482.(2010) (SCI)
    162. Yu, B.Y., S.W. Hu, Y.M. Sun, Y.T. Lee, and T.H. Young, Modulating the Activities of Human Mesenchymal Stem Cells (hMSCs) and C3A/HepG2 Hepatoma Cells by Modifying the Surface Characteristics of Poly(3-hydroxybutyrate-co-3-hydroxyhexnoate) (PHBHHx). Journal of Biomaterials Science-Polymer Edition. 20(9): p. 1275-1293.(2009) (SCI)
    163. Yu, B.Y., C.R. Chen, Y.M. Sun, and T.H. Young, The response of rat cerebellar granule neurons (rCGNs) to various polyhydroxyalkanoate (PHA) films. Desalination. 245(1-3): p. 639-646.(2009) (SCI)
    164. Young, T.H., H.R. Tu, C.C. Chan, Y.C. Huang, M.H. Yen, N.C. Cheng, H.C. Chiu, and S.J. Lin, The enhancement of dermal papilla cell aggregation by extracellular matrix proteins through effects on cell-substratum adhesivity and cell motility. Biomaterials. 30(28): p. 5031-5040.(2009) (SCI)
    165. Young, T.H., U.H. Lin, D.J. Lin, H.H. Chang, and L.P. Cheng, Immobilization of L-Lysine on Microporous PVDF Membranes for Neuron Culture. Journal of Biomaterials Science-Polymer Edition. 20(5-6): p. 703-720.(2009) (SCI)
    166. Yeh, L.K., Y.H. Chen, C.S. Chiu, F.R. Hu, T.H. Young, and I.J. Wang, The phenotype of bovine corneal epithelial cells on chitosan membrane. Journal of Biomedical Materials Research Part A. 90A(1): p. 18-26.(2009) (SCI)
    167. Yang, T.L. and T.H. Young*, The specificity of chitosan in promoting branching morphogenesis of progenitor salivary tissue. Biochemical and Biophysical Research Communications. 381(4): p. 466-470.(2009) (SCI)
    168. Yang, T.L. and T.H. Young*, Chitosan cooperates with mesenchyme-derived factors inregulating salivary gland epithelial morphogenesis. Journal of Cellular and Molecular Medicine. 13(9A): p. 2853-2863.(2009) (SCI)
    169. Yang, S.J., M.J. Shieh, F.H. Lin, P.J. Lou, C.L. Peng, M.F. Wei, C.J. Yao, P.S. Lai, andT.H. Young, Colorectal cancer cell detection by 5-aminolaevulinic acid-loaded chitosan nano-particles. Cancer Letters. 273(2): p. 210-220.(2009) (SCI)
    170. Shao, H.J., C.S. Chen, I.C. Lee, J.H. Wang, and T.H. Young, Designing a Three-dimensional Expanded Polytetrafluoroethylene-Poly(lactic-co-glycolic acid) Scaffold for Tissue Engineering. Artificial Organs. 33(4): p. 309-317.(2009) (SCI)
    171. Lou, P.J., W.F. Cheng, Y.C. Chung, C.Y. Cheng, L.H. Chiu, and T.H. Young*, PMMA particle-mediated DNA vaccine for cervical cancer. Journal of Biomedical Materials Research Part A. 88A(4): p. 849-857.(2009) (SCI)
    172. Lin, D.J., D.T. Lin, T.H. Young, T.C. Chen, H.H. Chang, and L.P. Cheng, Immobilization of DNA on Microporous PVDF Membranes by Plasma Polymerization. Journal of Biomaterials Science-Polymer Edition. 20(13): p. 1943-1959.(2009) (SCI)
    173. Lee, I.C., Y.T. Lee, B.Y. Yu, J.Y. Lai, and T.H. Young*, The behavior of mesenchymal Stem cells on micropatterned PLLA membranes. Journal of Biomedical Materials Research Part A. 91A(3): p. 929-938.(2009) (SCI)
    174. Huang, T.W., Y.H. Young, P.W. Cheng, Y.H. Chan, and T.H. Young*, Culture of Nasal Epithelial Cells Using Chitosan-Based Membranes. Laryngoscope. 119(10): p. 2066-2070.(2009) (SCI)
    175. Huang, C.W., J.Y. Cheng, M.H. Yen, and T.H. Young, Electrotaxis of lung cancer cells in a multiple-electric-field chip. Biosensors & Bioelectronics. 24(12): p. 3510-3516.(2009) (SCI)
    176. Huang, C.H., M.H. Chen, T.H. Young, J.H. Jeng, and Y.J. Chen, Interactive Effects of Mechanical Stretching and Extracellular Matrix Proteins on Initiating Osteogenic Differentiation of Human Mesenchymal Stem Cells. Journal of Cellular Biochemistry. 108(6): p. 1263-1273.(2009) (SCI)
    177. Chen, Y.H., I.J. Wang, and T.H. Young, Formation of Keratocyte Spheroids on Chitosan-Coated Surface Can Maintain Keratocyte Phenotypes. Tissue Engineering Part A. 15(8): p. 2001-2013.(2009) (SCI)
    178. Chen, R.S., Y.J. Chen, M.H. Chen, and T.H. Young, The behavior of rat tooth germ cells on poly(vinyl alcohol). Acta Biomaterialia. 5(4): p. 1064-1074.(2009) (SCI)
    179. Chen, R.S., M.H. Chen, and T.H. Young*, Induction of differentiation and mineralization in rat tooth germ cells on PVA through inhibition of ERK1/2. Biomaterials. 30(4): p. 541-547.(2009) (SCI)
    180. Chen, M.H., Y.J. Chen, C.C. Liao, Y.H. Chan, C.Y. Lin, R.S. Chen, and T.H. Young*, Formation of salivary acinar cell spheroids in vitro above a polyvinyl alcohol-coated surface. Journal of Biomedical Materials Research Part A. 90A(4): p. 1066-1072.(2009) (SCI)
    181. Chen, C.R., Y.C. Li, and T.H. Young*, Gallium nitride induces neuronal differentiation markers in neural stem/precursor cells derived from rat cerebral cortex. Acta Biomaterialia. 5(7): p. 2610-2617.(2009) (SCI)
    182. Yu, B.Y., P.Y. Chen, Y.M. Sun, Y.T. Lee, and T.H. Young, The behaviors of human mesenchymal stem cells on the (SCI)poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) membranes. Desalination. 234(1-3): p. 204-211.(2008) (SCI)
    183. Young, T.H., J.N. Lu, D.J. Lin, C.L. Chang, H.H. Chang, and L.P. Cheng, Immobilization of l-lysine on dense and porous poly(vinylidene fluoride) surfaces for neuron culture. Desalination. 234(1-3): p. 134-143.(2008) (SCI)
    184. Young, T.H., C.Y. Lee, H.C. Chiu, C.J. Hsu, and S.J. Lin, Self-assembly of dermal papilla cells into inductive spheroidal microtissues on poly(ethylene-co-vinyl alcohol) membranes for hair follicle regeneration. Biomaterials. 29(26): p. 3521-3530.(2008) (SCI)
    185. Yang, T.L. and T.H. Young*, The enhancement of submandibular gland branch formation on chitosan membranes. Biomaterials. 29(16): p. 2501-2508.(2008)
    186. Yang, T.L., Y.C. Hsiao, and T.H. Young*, Comparison of Plga, Pcl, and Chitosan in Salivary Gland Branching Morphogenesis. Biomedical Engineering-Applications Basis Communications. 20(5): p. 287-296.(2008) (SCI)
    187. Tseng, C.L., S.Y.H. Wu, W.H. Wang, C.L. Peng, F.H. Lin, C.C. Lin, T.H. Young, and M.J. Shieh, Targeting efficiency and biodistribution of biotinylated-EGF-conjugated gelatin nanoparticles administered via aerosol delivery in nude mice with lung cancer. Biomaterials. 29(20): p. 3014-3022.(2008) (SCI)
    188. Tan, H.Y., M.G. Lin, W.C. Hsiao, S.J. Lin, L.K. Wen, W.L. Chen, C.Y. Dong, and T.H. Young, Characterizing phase-separated microstructure of polymeric blended membrane using combined multiphoton and reflected confocal imaging. Optics Express. 16(6): p. 3818-3827.(2008) (SCI)
    189. Sun, Y., H.Y. Tan, S.J. Lin, H.S. Lee, T.Y. Lin, S.H. Jee, T.H. Young, W. Lo, W.L. Chen, and C.Y. Dong, Imaging tissue engineering scaffolds using multiphoton microscopy. Microscopy Research and Technique. 71(2): p. 140-145.(2008) (SCI)
    190. Cheng, J.Y., M.H. Yen, C.T. Kuo, and T.H. Young, A transparent cell-culture microchamber with a variably controlled concentration gradient generator and flow field rectifier. Biomicrofluidics. 2(2).(2008) (SCI)
    191. Chen, Y.J., C.H. Huang, I.C. Lee, Y.T. Lee, M.H. Chen, and T.H. Young*, Effects of cyclic mechanical stretching on the mRNA expression of tendon/ligament-related and osteoblast-specific genes in human mesenchymal stem cells. Connective Tissue Research. 49(1): p. 7-14.(2008) (SCI)
    192. Chen, R.S., Y.J. Chen, M.H. Chen, and T.H. Young, Cell-surface interactions of rat tooth germ cells on various biomaterials (vol 83, pg 241, 2007). Journal of Biomedical Materials Research Part A. 84A(2): p. 567-567.(2008) (SCI)
    193. Chen, C.R. and T.H. Young*, Neurons cultured on GaN and is associated with synapsin I and MAP2 expression. Biomedical Engineering-Applications Basis Communications. 20(2): p. 75-82.(2008) (SCI)
    194. Chen, C.R. and T.H. Young*, The effect of gallium nitride on long-term of neuritic function in cerebellar culture induced aging granule cells. Biomaterials. 29(11): p. 1573-1582.(2008) (SCI)
    195. Young, T.H.*, T.N. Shiau, and Z.H. Kuo, Dynamic stability of rotor-bearing systems subjected to random axial forces. Journal of Sound and Vibration. 305(3): p. 467-480.(2007) (SCI)
    196. Wang, T.W., H.C. Wu, W.R. Wang, F.H. Lin, P.J. Lou, M.J. Shieh, and T.H. Young, The development of magnetic degradable DP-Bioglass for hyperthermia cancer therapy. Journal of Biomedical Materials Research Part A. 83A(3): p. 828-837.(2007) (SCI)
    197. Wang, C.C., J.N. Lu, and T.H. Young*, The alteration of cell membrane charge after cultured on polymer membranes. Biomaterials. 28(4): p. 625-631.(2007) (SCI)
    198. Tseng, C.L., T.W. Wang, G.C. Dong, S.Y.H. Wu, T.H. Young, M.J. Shieh, P.J. Lou, and F.H. Lin, Development of gelatin nanoparticles with biotinylated EGF conjugation for lung cancer targeting. Biomaterials. 28(27): p. 3996-4005.(2007) (SCI)
    199. Lee, I.C., J.H. Wang, Y.T. Lee, and T.H. Young*, The differentiation of mesenchymal stem cells by mechanical stress or/and co-culture system. Biochemical and Biophysical Research Communications. 352(1): p. 147-152.(2007) (SCI)
    200. Lee, I.C., J.H. Wang, Y.T. Lee, and T.H. Young*, Development of a useful technique to discriminate anterior cruciate ligament cells and mesenchymal stem cells - The application of cell electrophoresis. Journal of Biomedical Materials Research Part A. 82A(1): p. 230-237.(2007) (SCI)
    201. Lai, P.S., P.J. Lou, C.L. Peng, C.L. Pai, W.N. Yen, M.Y. Huang, T.H. Young, and M.J. Shieh, Doxorubicin delivery by polyamidoamine dendrimer conjugation and photochemical internalization for cancer therapy. Journal of Controlled Release. 122(1): p. 39-46.(2007) (SCI)
    202. Hung, K.C., C.C. Yong, Y.S. Chen, H.L. Eng, F.Y. Kuo, C.C. Lin, T.H. Young, E. Kobayashi, C.L. Chen, and C.C. Wang, A surgical model of fulminant hepatic failure in rabbits. Liver International. 27(10): p. 1333-1341.(2007) (SCI)
    203. Cheng, J.Y., M.H. Yen, W.C. Hsu, J.H. Jhang, and T.H. Young, ITO patterning by a low power Q-switched green laser and its use in the fabrication of a transparent flow meter. Journal of Micromechanics and Microengineering. 17(11): p. 2316-2323.(2007) (SCI)
    204. Chen, R.S., Y.J. Chen, M.H. Chen, and T.H. Young, Cell-surface interactions of rat tooth germ cells on various biomaterials. Journal of Biomedical Materials Research Part A. 83A(1): p. 241-248.(2007) (SCI)
    205. Chang, K.Y., L.W. Chen, T.H. Young, and K.H. Hsieh, PEI/EVAL blend membranes for granule neuronal cell culture. Journal of Polymer Research. 14(3): p. 229-243.(2007) (SCI)
  2. Conference Papers

    1. TH Young, Polymer membrane changes surface charge properties of cell membrane, MACRO 2004- 40th IUPAC World Polymer Congress.
    2. TH Young, Covalent bonding of amino acids to EVAL and PVA membranes for culturing of neuron cells, The International Congress on Membranes and Membrane Processes, ICOM 2002.
    3. TH Young, Assessment of poly (vinyl alcohol) bioartificial pancreas in vivo, SOCIETY FOR BIOMATERIALS, 27th Annual Meeting, 2001.
    4. TH Young, 5-ASA permeability enhancement by a pH-Sensitive EVAL membrane, 2001 Prague Meetings on Macromolecules, 41th Microsymposium, Polymer Membranes.
  3. Books and Chapter in Book

    1. KH Hsieh and TH Young, Hydrogel Biomaterials, JC Salamone ed., Polymeric Materials Encyclopedia, (1996) 3087-3092.
  4. Awards

    1. 財團法人宗倬章先生教育基金會「宗倬章先生講座」,2019
    2. Fellow, American Institute for Medical and Biological Engineering, 2016.
    3. YH Wang, TH Young, TJ Wang, Investigation of Chitosan/Polycaprolactone Blends for Corneal Endothelial Tissue Engineering, the Best Poster at the APAO 2016 Congress.
    4. 行政院科技部104年度傑出研究獎(MOST Outstanding Research Award, 2015-2017).
    5. 財團法人李昭仁教授生醫工程發展基金會研究學者獎, 2015.
    6. 李亦宸, 101 學年度臺大醫學院研究生優秀著作獎優等獎。
    7. 鄭乃禎, 101 學年度臺大醫學院研究生優秀著作獎優等獎。
    8. 鄭乃禎, 楊台鴻, 「財團法人全球展望醫學基金會」博士班研究生優秀論文獎金質獎 2012.
    9. 李亦宸, 鄒亞璇, 楊台鴻, 2012中華民國生物醫學工程創意設計、製作競賽,永康技術獎.
    10. 鄭乃禎, 王珊, 楊台鴻, Spheroid formation of human adipose-derived stem cells on chitosan films enhances stemness and differentiation capabilities, 2012年再生醫學會年會論文口頭報告競賽第一名.
    11. 行政院國家科學委員會100年度傑出研究獎(NSC Outstanding Research Award, 2011-2013)。
    12. RW Chang, KC Chang, TH Young, CH Wang, YS Chen, WJ Ko, SS Wang, Atorvastatin Prevents Arterial Stiffening in Streptozotocin-Induced Diabetic Rats, ASVS (Asia Society for Vascular Surgery) 2011 oral presentation second prize
    13. 李亦宸 林泳沖 楊台鴻, A culture micro-environment for neural stem/precursor cells, 2011年高分子學會年會論文口頭報告競賽優勝.
    14. 邵宏仁 楊台鴻,Modulation of gene expression and collagen production of anterior cruciate ligament cells through cell shape changes on polycaprolactone/chitosan blends, 99學年度「研究生優秀論文著作獎」.
    15. 經濟部全國標準化獎個人成就獎(National Standardization Award), 2010.
    16. 台灣大學特聘教授(NTU Chair Professor),2010-2013.
    17. 行政院國家科學委員會九十八年度傑出學者研究計畫 (NSC Outstanding Scholar Research Grant, 2009-2012)。
    18. 陳蓉書 楊台鴻,Induction of differentiation and mineralization in rat tooth germ cells on PVA through inhibition of ERK1/2, 98學年度「研究生優秀論文著作獎」.
    19. 楊宗霖、楊台鴻,唾液腺分枝構造之組織工程,2008第六屆國家新創獎學生組第二名。
    20. Edith J. Crawley Memorial International Scholar Award, 2007.
    21. 台大特聘教授(NTU Chair Professor),2007-2010.
    22. 台大教學優良獎,2007.
    23. 陳啟瑞,楊台鴻,氮化鎵應用於神經生物晶片之可行性評估,2006第四屆國家新創獎學生組第三名。
    24. 陸瑞男,楊台鴻,Outstanding paper award in the International Conference of Biomedical & Pharmaceutical Engineering, Interaction of HepG2 cells on biomaterials with various surface properties, 2006 (Singapore).
    25. International Research Scholar Award of Research to Prevent Blindness (RPB), USA, 2005.
    26. 行政院國家科學委員會九十三年度傑出研究獎(NSC Outstanding Research Award, 2004-2006)。
    27. Best poster paper award in the 4th Conference on Membrane Science & Technology, Polymer membranes change surface charge of cell membranes, 2004.
    28. 中華民國生物醫學工程學會壁報論文佳作獎:黑色素細胞培養於耐龍/幾丁聚糖掺合薄膜之研究,中華民國九十二年。
    29. 中國化學工程學會傑出論文獎:金屬濺鍍對高分子薄膜結構的影響,中華民國九十一年。
    30. 中國工程師學會工程論文獎:金屬濺鍍對高分子薄膜結構的影響,中華民國九十一年。
    31. 國科會一般獎甲種: The formation mechanism of membranes prepared from the crystalline EVAL polymer- water (nonsolvent)- 2-propanol (nonsolvent) system,中華民國八十九年。
    32. 國科會一般獎甲種: Membranes with a particulate morphology prepared by a dry-wet casting process,中華民國八十八年。
    33. 國科會一般獎甲種: Phase behavior of EVAL polymers in water-2-propanol cosolvent,中華民國八十七年。
    34. 中國材料科學學會材料科學海報論文獎:薄膜表面結構對神經修復系統之影響,中華民國八十六年。
    35. 國科會一般獎甲種: Use of a diffusion model for assessing the performance of poly (vinyl alcohol) bioartificial pancreas,中華民國八十六年。
    36. 國科會一般獎甲種: Membranes with a microparticulate morphology,中華民國八十四年。
  5. Plenary Lecture or Invited Lecture

    1. Chitosan-based materials in salivary gland tissue engineering, Biomaterials Asia 2009,香港,April, 2009.
    2. The role of serum in proliferation and differentiation-promoting effects on neural stem/precursor cells, The 3rd Asian Biomaterials Congress, Busan, Republic of Korea, 2011.
    3. A novel neuronal differentiation system: Combination of culture medium and biomaterial for neural stem precursor cells. International symposium on recent advances in pluripotent stem cells, Taipei, 2011.
    4. Development and Application of MIS Medical Device, 3rd Taipei International Symposium of Minimal Invasive Digestive Surgery , 2014.
  6. Patents





    申請國別 發明人





    111104802 中華民國


    連續型細胞生產系統及方法 一種連續型細胞生產系統,包括:一培養容器;及一高分子混摻層,設置於該培養容器內表面;其中,該高分子混摻層係酸鹼應答型高分子混摻耐綸。
    110132918 中華民國


    一種生物相容之帶狀材料的用途、使用方法及折疊結構體 一種生物相容之帶狀材料的用途,其係用於在體外製備為植入關節中的間隔物,其中該 帶狀材料:選自熱塑性聚氨酯、矽膠、聚四氟乙烯、聚己內酯、聚乳酸及具可塑性的高 分子材料所組成之群組;及/或可彎曲且蕭氏硬度為20A 至 100A;其中,該間隔物係該 帶狀材料經折疊所形成之折疊結構體。
    109119984 中華民國 楊台鴻
    定位導引裝置 一種定位導引裝置,包括:一定位中空管體,具有一容納空間;一輔助針頭,為一中空 管體,其內徑大於該定位中空管體之外徑以套設於該定位中空管體之外側;以及一定位 縫線,包括一縫線本體及連接該縫線本體之一頭部,該頭部具有對應設置之一頂端以及 一尾端,該頂端為一閉合端,該頭部一最寬處之一直徑與該定位中空管體之內徑對應而 令該定位縫線得容納於該容納空間之中;其中,該輔助針頭插入一待切除組織後,該定 位中空管體沿著該輔助針頭的內徑插入該待切除組織,且當注入該定位縫線至該待切除 組織時,該頭部及該縫線本體的一部份在該待切除組織內部,該縫線本體的其他部分露 出於該待切除組織外。
    109110663 中華民國 楊台鴻
    烯丙胍聚合物及其製備方法與應用 一種烯丙胍聚合物,包含式(1)所表示之重複單元:其中,n 為 50~200 及/或該烯丙胍聚合物之平均分子量為 4957~19828。
    109104372 中華民國 王一中
    一種角膜植入之組合物及其用途與製備方法 一種角膜植入之組合物,包含:一膠原蛋白薄膜;及一近端腎小管細胞,貼附於該膠原 蛋白薄膜;其中該近端腎小管細胞於該膠原蛋白薄膜上之密度約為 5×104 細胞/平方公分 (cells/cm2 )至 5×106 細胞/平方公分(cells/cm2 )。