Department of Biomedical Engineering, NTU-HSIANG-KUANG TONY LIANG

HSIANG-KUANG TONY LIANG

Journal Papers(corresponding author)*
1. Yun-Cong Zheng, Johnny Chuieng-Yi Lu, Tommy Nai-Jen Chang, Yenpo Lin, Yu-Ching Lin, Jung-Yu Kuo, Janice Tania, Yi-Ting Liao, Yi-Ping Tseng, Hsiang-Kuang Tony Liang*, David Chwei-Chin Chuang. Preoperative MRI segmentation of paraspinal muscles is associated with intraoperative findings of traumatic brachial plexus injury. Radiology. 2025;316(2):e242177.
  (IF: 15.2; Rank: 0.47%, 1/212, RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING, 台大醫工與長庚醫療體系合作研究, 2025 國家新創獎)
2. Cheng-Yi Hsu, Jason Lin, Ming-Feng Wei, Liang-Hsin Chen, Hsiang-Kuang Tony Liang*, Feng-Huei Lin. Local delivery of carboplatin-loaded hydrogel and calcium carbonate enables two-stage drug release for limited-dose radiation to eliminate mouse malignant glioma. Biomaterials. 2025;312:122746.
  (SCI, IF: 12.9; Rank: 3/122, ENGINEERING, BIOMEDICAL, co-first author, NSTC)
3. Chang-Shiun Lin, Yi-Chun Tsai, Chun-Wei Wang, Liang-Hsin Chen, Hsiang-Chin Lu, Tsung-Yu Lin, Chia-Jung Wu, Li-Chien Wei, Hsiang-Kuang Liang, Sung-Hsin Kuo. A method to obtain optimal relative electron densities of metallic samples for a density scaling-based commercial photon dose calculation algorithm. Radiation Physics and Chemistry. 2025;229:112520.
  (IF: 3.4; Rank: 12/39; Category: PHYSICS, ATOMIC, MOLECULAR & CHEMICAL)
4. Yen-Ting Liu, Kuan-An Chu, Shih-Ting Huang, Chia-Wei Shen, Jia-Hung Liou, Hsiang-Kuang Tony Liang, Sung-Hsin Kuo. The toxicity of hybrid techniques combining hypofractionated whole breast radiotherapy with concomitant tumor bed boost in patients with breast cancer. Journal of the Formosan Medical Association. Available online 8 October 2025.
  (IF: 2.6; Rank: 74/332, MEDICINE, GENERAL & INTERNAL)
5. Chun-Wei Wang, Bing-Shen Huang, Hsiang-Kuang Liang, Wan-Yu Chen. Nasopharyngeal Carcinoma in Intensity-Modulated Radiation Therapy Era: Competing-Risk Analysis, Recurrence, and Postrecurrence Survival. Head & Neck. 2025 Nov;47(11):3076-3085.
  (IF: 2.442; Rank: 23.81%, 10/42, OTORHINOLARYNGOLOGY)
6. Szu-Huai Lu, Chun-Wei Wang, Hsiang-Kuang Liang, Chih-Kai Chang, Hao-Ting Lan, Shih-Fan Lai, Bing-Shen Huang, Wan-Yu Chen. Knowledge-Based RapidPlan Volumetric Modulated Arc Therapy Model in Nasopharyngeal Carcinoma. Advances in Radiation Oncology. 2025 Jan 13;10(5):101716.
  (IF: 2.7; Rank: 38.44%, 133/346, RADIOLOGY, NUCLEAR MEDICINE AND IMAGING)
7. Min-Hua Chen, Xiang-Hao Zeng, Yi-Ting Shu, Hsiang-Kuang Liang, Ching-Yun Chen, Chun-Yu Lin, Cheng-An J Lin, Jen-Kun Chen. Biodegradable hafnium-doped CaCO3 nanoparticles as a dual-modality radiosensitizer for cancer radiotherapy. Nanomedicine. 2024;19(13):1133-1144.
  (IF: 5.4; Rank: 26.15%, 34/130, NANOSCIENCE & NANOTECHNOLOGY)
8. Yen-Ting Liu, Yi-Hsing Chen, Chen-Han Chang, Hsiang-Kuang Tony Liang. Recurrent fibroblast growth factor receptor3 fusion glioblastoma treated with pemigatinib: A case report and review of the literature. Neuro-Oncology Advances. 2024 May 14;6(1):vdae072.
  (IF: 4.2; Rank: 60/244, ONCOLOGY)
9. Chang-Shiun Lin, Yi-Chun Tsai, Liang-Hsin Chen, Chun-Wei Wang, Chia-Jung Wu, Wan-Yu Chen, Hsiang-Kung Liang, Sung-Hsin Kuo. Effect of extended field-of-view approaches on the accuracy of stopping power ratio estimation for single-energy computed tomography simulators. Journal of Applied Clinical Medical Physics. 2023 Sep;24(9):e14010.
  (IF: 2.1; Rank: 87/134, RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING)
10. Wan-Yu Chen, Szu-Huai Lua, Yu-Ming Wang, Chun-Wei Wang, Ku-Hao Fang, Shih-Fan Lai, Hsiang-Kuang Liang, Bing-Shen Huang. Post-irradiation sarcoma after definitive radiation therapy for nasopharyngeal carcinoma. Radiotherapy and Oncology. 2023;178:109423.
  (SCI, IF: 6.3; Rank: 18/134; RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING)
11. Szu-Huai Lu, Hao-Ting Lan, Yi-Chun Tsai, Ya-Fang Chen, Shih-Fan Lai, Hsiang-Kuang Liang, Bing-Shen Huang, Wan-Yu Chen, Chun-Wei Wang. Vertebral artery sparing volumetric modulated arc therapy in nasopharyngeal carcinoma. Medical Dosimetry. 2023;48(4):304-311.
  (IF: 1.8; Rank: 92/134; RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING)
12. Hsiang-Kuang Tony Liang*, Hideyuki Takei, Tetsuya Tomita, Toshiyuki Terunuma, Tomonori Isobe, Toshiyuki Okumura, Takeji Sakae, Hideyuki Sakurai. Analysis of diaphragm movements to specify geometric uncertainties of respiratory gating near end-exhalation for irradiation fields involving the liver dome. Radiotherapy and Oncology. 2022;171:146-154.
  (SCI, IF: 6.3; Rank: 18/134; Category: RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING, 台灣大學與日本筑波大學質子治療中心合作研究, co-first author)
13. Min-Hua Chen, Chun-HungLee, Hsiang-Kuang Liang, Su-Chin Huang, Jui-PingLi, Cheng-An J. Lin, Jen-Kun Chen. Integrating the microneedles with carboplatin to facilitate the therapeutic effect of radiotherapy for skin cancers. Biomaterials Advances. 2022;141:213113.
  (IF: 9.0; Rank: 9/98, MATERIALS SCIENCE, BIOMATERIALS)
14. Yi-Chun Tsai, Chia-Chun Wang, Chun-Wei Wang, Hsiang-Kuang Liang, Shu-Fan Wang. Efficient method for whole-breast irradiation therapy using Halcyon linear accelerators. Medical Dosimetry. 2022;47(3):240-246.
  (IF: 1.8; Rank: 92/134; Category: RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING)
15. Hsiang-Kuang Tony Liang, Masashi Mizumoto, Eiichi Ishikawa, Masahide Matsuda, Keiichi Tanaka, Hidehiro Kohzuki, Haruko Numajiri, Yoshiko Oshiro, Hitoshi Ishikawa, Toshiyuki Okumura, Koji Tsuboi, Akira Matsumura, Hideyuki Sakurai. Peritumoral edema status of glioblastoma identifies patients reaching long-term disease control with specific progression patterns after tumor resection and high-dose proton boost. Journal of Cancer Research and Clinical Oncology. 2021;147:3503-3516.
  (SCI, IF: 4.6; Rank: 92/322, ONCOLOGY, 台灣大學與日本筑波大學質子治療中心合作研究)
16. Hsiang-Kuang Liang. International Perspective of Proton Beam Therapy Development Strategies in Taiwan (Full text in Chinese: Formosan J Med 2020;24:533-41)
17. Wan-Yu Chen, Ku-Hao Fang, Chun-Wei Wang, Chun-Ta Liao, Tzu-Chen Yen, Taun-Jen Fang, Shih-Fan La, Hsiang-Kuang Liang, Bing-Shen Huang. Adjuvant therapy may be omitted for oral cavity cancer with only one positive lymph node. Laryngoscope Investigative Otolaryngology. 2021;6(6):1339-1346.
  (IF: 2.4; Rank: 18/44, OTORHINOLARYNGOLOGY)
18. Masashi Mizumoto, Hsiang-Kuang Liang, Yoshiko Oshiro, Masahide Matsuda, Hidehiro Kohzuki, Takashi Iizumi, Haruko Numajiri, Kei Nakai, Toshiyuki Okumura, Eiichi Ishikawa, Hideyuki Sakurai. Radiation Therapy for Grade 3 Gliomas: Correlation of MRI Findings With Prognosis. Cureus. 2021;doi:10.7759/cureus.16887.
  (SCI, IF: 0.27; Rank: 22.82%, 34/149, MEDICINE, GENERAL AND INTERNAL, Research collaboration of National Taiwan University and University of Tsukuba)
19. Yi-Wei Chen, Yi-Yen Lee, Chun-Fu Lin, Po-Shen Pan, Jen-Kun Chen, Chun-Wei Wang, Shih-Ming Hsu, Yu-Cheng Kuo, Tien-Li Lan, Sanford P. C. Hsu, Muh-Lii Liang, Robert Hsin-Hung Chen, Feng-Chi Chang, Chih-Chun Wu, Shih-Chieh Lin, Hsiang-Kuang Liang, Jia-Cheng Lee, Shih-Kuan Chen, Hong-Ming Liu, Jinn-Jer Peir, Ko-Han Lin, Wen-Sheng Huang, Kuan-Hsuan Chen, Yu-Mei Kang, Shueh-Chun Liou, Chun-Chieh Wang, Ping-Ching Pai, Chih-Wei Li, Daniel Quah Song Chiek, Tai-Tong Wong, Shih-Hwa Chiou, Yee Chao, Hiroki Tanaka, Fong-In Chou, and Koji Ono (2021, Apr). Salvage Boron Neutron Capture Therapy for Malignant Brain Tumor Patients in Compliance with Emergency and Compassionate Use: Evaluation of 34 Cases in Taiwan. Biology. 10(4), 334.
  (SCI, IF: 3.5; Rank: Q1, BIOLOGY)
20. Wan-Yu Chen, Tseng-Cheng Chen, Shih-Fan Lai, Tony Hsiang-Kuang Liang, Bing-Shen Huang, Chun-Wei Wang. Outcome of bimodality definitive chemoradiation does not differ from that of trimodality upfront neck dissection followed by adjuvant treatment for >6 cm lymph node (N3) head and neck cancer. PLoS One. 2019;14(12):e0225962.
  (SCI, IF: 2.6; Rank: 44/136, MULTIDISCIPLINARY SCIENCE)
21. Shih-Fan Lai, Yu-Hsuan Chen, Tony Hsiang-Kuang Liang, Che-Yu Hsu, Huang-Chun Lien, Yen-Sen Lu, Chiun-Sheng Huang, Sung-Hsin Kuo. The breast graded prognostic assessment is associated with the survival outcomes in breast cancer patients receiving whole brain re-irradiation. J Neurooncol. 2018;138:637-647.
  (SCI, IF: 3.9; Rank: 70/209, CLINICAL NEUROLOGY)
22. Hsiang-Kuang Tony Liang and Wen-Yih Isaac Tseng. Response to ‘Perilesional edema in brain cancer: independent prognosticator or epiphenomenon of biomolecular signature?’ Radiotherapy and Oncology. 2018;129:185-186.
  (IF: 2.6; Rank: 44/136, RADIOLOGY, NUCLEAR MEDICINE AND IMAGING)
23. Hsiang-Kuang Tony Liang, Xue-Shi Lai, Ming-Feng Weib, Szu-Huai Lu, Wen-Fen Wen, Sung-Hsin Kuo, Chung-Ming Chen, Wen-Yih Isaac Tseng, and Feng-Huei Lin. Intratumoral injection of thermogelling and sustained-release carboplatin-loaded hydrogel simplifies the administration and remains the synergistic effect with radiotherapy for mice gliomas. Biomaterials. 2018;151:38-52.
  (SCI, IF: 10.273; Rank: 3.75%, 3/80, ENGINEERING, BIOMEDICAL)
24. Hsiang-Kuang Tony Liang, Wan-Yu Chen, Shih-Fan Lai, Mao-Yuan Su, San-Lin You, Liang-Hsin Chen, Ham-Min Tseng, Chung-Ming Chen, Sung-Hsin Kuo, and Wen-Yih Isaac Tseng. The extent of edema and tumor synchronous invasion into the subventricular zone and corpus callosum classify outcomes and radiotherapy strategies of glioblastomas. Radiotherapy and Oncology. 2017;125:248-257.
  (SCI, IF: 5.3, RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING)
25. Tony Hsiang-Kuang Liang, Sung-Hsin Kuo, Chun-Wei Wang, Wan-Yu Chen, Che-Yu Hsu, Shih-Fan Lai, Ham-Min Tseng, San-Lin You, Chung-Ming Chen, and Wen-Yih Isaac Tseng. Adverse prognosis and distinct progression patterns after concurrent chemoradiotherapy for glioblastoma with synchronous subventricular zone and corpus callosum invasion. Radiotherapy and Oncology. 2016;118:16-23.
  (SCI, IF: 5.252; Rank: 10.85%, 14/129, RADIOLOGY, NUCLEAR MEDICINE AND IMAGING)
26. Chen WY, Kuo SH, Shen CW, Huang BS, Lan KH, Liang HK, Wang CW. Good tolerance and long-term complete remission after definitive intensity-modulated radiotherapy for locally advanced head and neck cancer in a patient with human immunodeficiency virus infection: A case report and literature review. Head Neck. 2015;37(12):E186-90.
  (SCI, IF: 2.442; Rank: 23.81%, 10/42, OTORHINOLARYNGOLOGY)
27. Wang CW, Lin YC, Tseng HM, Xiao F, Chen CM, Cheng WL, Lu SH, Lan KH, Chen WY, Liang HK, Kuo SH. Prolonged treatment time deteriorates positioning accuracy for stereotactic radiosurgery. PLoS One. 2015;10(4):e0123359.
  (SCI, IF: 2.776; Rank: 34.78%, 24/69, MULTIDISCIPLINARY SCIENCE)
28. Hsiang-Kuang Liang, Chun-Wei Wang, Han-Min Tseng, Chao-Yuan Huang, Keng-Hsueh Lan, Yu-Hsuan Chen, San-Lin You, Jason Chia-Hsien Cheng, Ann-Lii Cheng, and Sung-Hsin Kuo. Preoperative Prognostic Neurologic Index for Glioblastoma Patients Receiving Tumor Resection. Ann Surg Oncol. 2014;21:3992-3998.
  (SCI, IF: 3.681; Rank: 13.30%, 27/203, SURGERY)
29. Hsiang-Kuang Liang, Chao-Yuan Huang, Chun-Wei Wang, Yu-Hsuan Chen, Sung-Hsin Kuo, Jason Chia-Hsien Cheng. Clinical Characteristics, Image Findings, and Treatment Modalities Associate with Outcomes of Patients with Glioblastoma Multiforme. Therapeutic Radiology and Oncology. 2012;19:93-104
Conference Papers(corresponding author)*
1. Meng-Yuan Chen, Hsiang-Kuang Tony Liang*. Scaling high-capacity ResEnc-UNet with dynamic batch size for universal brain tumor segmentation. The 28th International Conference on Medical Image Computing and Computer-Assisted Intervention. MICCAI 2025 / LNCS 16376 (published 2026), Springer. (Generalizability Task: Rank 1, oral presentation)
2. Meng-Yuan Chen, Hsiang-Kuang Tony Liang*. Memory-constrained, noise-resilient pediatric brain tumor segmentation via decoupled feature learning and domain adaptation. The 28th International Conference on Medical Image Computing and Computer-Assisted Intervention. MICCAI 2025 / LNCS 16376 (published 2026), Springer. (Pediatric Glioma Task: Rank 2, oral presentation)
3. Jason Lin, Wei-Yang Hong, Hsiang-Kuang Tony Liang*, Feng-Huei Lin*. Combination of Microparticles and Tissue Adhesive Gel for Local Treatment of High-grade Glioma. 33rd Annual Conference of the European Society for Biomaterials. 2023 Sep.
4. Ying-Ru Chen, Hsiang-Kuang Liang*. Utilizing energy deprivation of atovaquone to develop a drug delivery system synergizing with radiation to eradicate high-grade glioma. 2023 Annual Symposium of Taiwanese Society of Biomedical Engineering. 2023 Sep.
5. Jason Lin, Wei-Yang Hong, Hsiang-Kuang Tony Liang*, Feng-Huei Lin*. Combination of platinum-doped CaCO3 and amylopectin-based gel to synergize with radiotherapy for high-grade glioma. Annual Meeting of Taiwan Medicine Society. 2023 Aug. (1st Prize Best Student Oral Presentation)
6. Jason Lin, Wei-Yang Hong, Hsiang-Kuang Tony Liang*, Feng-Huei Lin*. Combination of Pt-doped Cacium Carbonate and Amylopectin-based Gel for Local Treatment of High-grade Glioma. 奈米生醫年會. 2023 Jul. (Rank 1, oral presentation)
7. Liang-Hsin Chen, Hsiang-Kuang Tony Liang*, Sung-Hsin Kuo. Evaluating environmental radiation dose to ensure radiation protection during the trial operation at National Taiwan University Proton Therapy Center. 61st Particle Therapy Co-Operative Group. 2023 Jun.
8. Liang-Hsin Chen, Yi-Chun Tsai, Hsiang-Kuang Liang*. Through Measurement-based QA Devices and Log-files-based QA Software to Check the Dose Delivery Accuracy of Halcyon Facility. 第22屆亞太區醫學物理學會國際學術研討會. 2022 Dec.
9. Kuan-An Chu, Shih-Ting Huang, Chia-Wei Shen, Sung-Hsin Kuo, Hsiang-Kuang Tony Liang, YenTing Liu. Combining step-and-shoot intensity modulated radiation therapy concomitant boost to tumor bed and 3D breast field-in-field plans for hypofractionated breast radiotherapy. 2022 ASTRO 美國放射腫瘤官方學術年會. 2022 Oct.
Oral Presentation
1. Symposium of Medical Imaging and Radiological Sciences, Nov 2023: Pei-An Chu, Hsiang-Kuang Tony Liang. Combining TiO2 loaded gel with radiotherapy to enhance anticancer effect for glioblastoma. (second place award oral presentation, NSTC grant)
2. 7^thJapan Taiwan Radiation Oncology Symposium, 2019: Hsiang-Kuang Tony Liang, Masashi Mizumoto, Eiichi Ishikawa, Masahide Matsuda, Hidehiro Kohzuki, Hitoshi Ishikawa, Toshiyuki Okumura, Koji Tsuboi, Akira Matsumura, Hideyuki Sakurai. Utilizing restrictive peritumoral edema status of glioblastoma to identify patients reaching long-term disease control after dose-escalated proton boost for developing personalized treatment strategies (Travel grant through Taiwan Society for Therapeutic Radiology and Oncology)
3. American Society for Radiation Oncology 59^th Annual Meeting, 2017: Hsiang-Kuang Tony Liang, Wan-Yu Chen, Shih-Fan Lai, Mao-Yuan Su, San-Lin You, Liang-Hsin Chen, Ham-Min Tseng, Chung-Ming Chen, Sung-Hsin Kuo, Wen-Yih Isaac Tseng. The extent of edema and tumor synchronous invasion into the subventricular zone and corpus callosum classify outcomes and radiotherapy strategies of glioblastomas (ePoster with oral presentation, travel grant through National Taiwan University)
4. 5^thJapan Taiwan Radiation Oncology Symposium, 2017: Hsiang-Kuang Tony Liang, Sung-Hsin Kuo, Chun-Wei Wang, Wan-Yu Chen, Che-Yu Hsu, Shih-Fan Lai, b, Ham-Min Tseng, San-Lin You, Chung-Ming Chen, and Wen-Yih Isaac Tseng. Adverse Prognosis and Distinct Progression Patterns After Concurrent Chemoradiotherapy for Glioblastoma With Synchronous Subventricular Zone and Corpus Callosum Invasion, Updated Report. (Travel grant through Taiwan Society for Therapeutic Radiology and Oncology)
5. 56^th Annual Conference of Particle Therapy Co-operative Group, Oral Presentation, 2017: Hsiang-Kuang Tony Liang, Masashi Mizumoto, Tetsuya Yamamoto, Daich Takizawa, Keiich Tanaka, Teruhito Aihara, Toshiyuki Okumura, Hitoshi Ishikawa, Koji Tsuboi, Hideyuki Sakurai. Edema extent of glioblastoma determined the survival and progression pattern after concurrent chemoradiotherapy with proton beam. (Travel grant through National Taiwan University and University of Tsukuba)
Posters
1. Hsiang-Kuang Tony Liang, Masashi Mizumoto, Kei Nakai, Wan-Yu Chen, Shih-Fan Lai, Chun-Wei Wang, Sung-Hsin Kuo, Hideyuki Sakurai. Edema extent of glioblastoma classified the survival after postoperative radiotherapy: comparison between conventional photon and high-dose proton boost radiotherapies. International Journal of Particle Therapy. 2024;12:100410. (poster)
2. Liang-Hsin Chen, Hsiang-Kuang Tony Liang*, Sung-Hsin Kuo. To verify coincidence between radiation and imaging isocenters and spot size stability in scanning proton beam through XRV-124 scintillator detector. International Journal of Particle Therapy. 2024;12:100548. (poster)
3. Ying-Ru Chen, Hsiang-Kuang Liang. Utilizing atovaquone-incorporated thermosensitive hydrogel to synergize with radiation by energy deprivation for high-grade glioma. World Biomaterials Congress 2024. 2024 May. (NSTC grant, poster)
4. Jason Lin, Wei-Yang Hong, Hsiang-Kuang Tony Liang*, Feng-Huei Lin*. Combination of Microparticles and Tissue Adhesive Gel for Local Treatment of High-grade Glioma. 33rd Annual Conference of the European Society for Biomaterials. 2023 Sep. (NSTC grant, poster)
5. Hsiang-Kuang Tony Liang, Hideyuki Takei, Tetsuya Tomita, Tomonori Isobe, Toshiyuki Okumura, Takeji Sakae, Hideyuki Sakurai. Integrating 4D and simulating CT imaging to evaluate liver dome deviations within different respiratory phases and associated proton dosimetry variations. 57th Annual Conference of Particle Therapy Co-operative Group. 2018. (Travel grant through National Taiwan University)
Media Coverage
1. Asia Research News (2025) “Novel MRI-Based Evaluation System Accurately Quantifies Paraspinal Muscle Atrophy and Nerve Root Injury Severity"：https://www.asiaresearchnews.com/content/novel-mri-based-evaluation-system-accurately-quantifies-paraspinal-muscle-atrophy-and-nerve
2. Asia Research News (2024) “Smart Two-Stage Carboplatin Release System: Synergizing with Reduced-Dose Radiotherapy to Eradicate Malignant Gliomas in Mice"：https://www.asiaresearchnews.com/content/smart-two-stage-carboplatin-release-system-synergizing-reduced-dose-radiotherapy-eradicate

Department of Biomedical Engineering, NTU

HSIANG-KUANG TONY LIANG

HSIANG-KUANG TONY LIANG

Journal Papers(corresponding author)*

Conference Papers(corresponding author)*

Oral Presentation

Posters

Media Coverage